Introduction: This systematic review aims to examine the effects of the CYP1A2 −163C>A and ADORA2A 1976T>C polymorphism on physiological effects and performance relative to caffeine consumption. Material and Methods: In this study, electronic databases including PubMed, Web of Science Core Collection, Korean Journal Database, Russian Science Citation Index, SciELO Citation Index, Scopus, ScienceDirect, ProQuest Dissertations & Thesis Global and EBSCO were searched. Results: The results highlight that individuals with the TT or CT/CC genotype can have differences in caffeine consumption, and C carriers may have increases in the maximum oxygen uptake (VO2max). The AA or AC/CC genotypes can have different caffeine consumption and VO2max. In four studies, TT or CT/CC either in AA or CC genotype had different physiological effects. Regardless of the amount of caffeine (3 mg/kg-5 mg/kg), Carriers of the C allele in the genotype ADORA2A gene have higher sports performance. Six studies revealed a significant correlation between the AA genotype and performance following caffeine intake. Conclusions: Genotype variations in ADORA2A and CYP1A2 may modulate the ergogenic effects of caffeine, but some physiological effects can occur for different genotypes.

Author ORCID Identifier

Rabia Rümeysa KOCATÜRK ORCID 0000-0001-6769-3057

İlke KARAGÖZ ORCID 0000-0002-3011-4899

Ebru YANIK ORCID 0000-0003-4165-4492

Öznur Özge ÖZCAN ORCID 0000-0001-8992-0556

Türker Tekin ERGÜZEL ORCID 0000-0001-8438-6542

Mesut KARAHAN ORCID 0000-0002-8971-678X

Nevzat TARHAN ORCID 0000-0002-6810-7096

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.